What does Serrapeptase do?

Serrapeptase is a powerful proteolytic enzyme formula that stands alone in fighting the combined threats of fibrin, mucous and inflammation in the body.

Serrapeptase is a protein digesting enzyme which breaks down "non living" matter in the human body. This may promote a reduction in levels of dead tissue in the circulatory system, promoting smoother healthier flowing blood. Fibrin often builds up throughout the body and manifest in many undesirable and unhealthy ailments. Serrapeptase fights fibrin build up in the cardiovascular system, organs and muscle tissue.

The late German physician, Dr. Hans Nieper, used Serrapeptase to treat arterial blockage in his coronary patients. He found that Serrapeptase helps against stroke and is reportedly more effective and quicker than EDTA Chelation treatments in removing arterial plaque. He also reports that Serrapeptase dissolves blood clots and causes varicose veins to shrink or diminish. Dr. Nieper told of a woman scheduled for hand amputation and a man scheduled for bypass surgery who both recovered quickly without surgery after treatment with Serrapeptase .

Studies and reports on the use of Serrapeptase are numerous and reports reference successful use with:

Dissolving non-living tissues to include blood clots, cysts and arterial plaque
As an anti-inflammatory agent
Sinusitis and for thinning mucous secretions
Removing Arterial Blockages
Rheumatoid Arthritis
Arthritis Pain and Inflammation
Varicose Veins
Fibrocystic Breasts

Serrapepetase - is a powerful proteolytic enzyme formula that stands alone in fighting the combined threats of fibrin, mucus and inflammation in the body. SerraRX80 is infused serrapeptase alone, no excipients or other products to obstruct, inhibit or in any other way negatively affect results.*

Serrapeptase - noun, ser·ra·pep·tase; a super protein digesting enzyme which breaks down "non living" matter in the human body. This action may promote a reduction in levels of dead tissue in the circulatory system, promoting smoother, healthier flowing blood and reduction of inflammation. Fibrin may build up throughout the body and manifest in many undesirable and unhealthy ailments including abnormal mucus build-up. Serrapeptase fights fibrin build-up in the cardiovascular system, organs, muscle tissue, and throughout the entire human body.*

A Potent Proteolytic Enzyme:

The inflammatory response is an important mechanism for protecting the body from attack by invading organisms and faulty cells. In the case of immune dis-regulation, the body loses its ability to differentiate between innocuous and potentially dangerous substances. This defective mechanisms results in a wide array of autoimmune diseases such as allergies, psoriasis, rheumatoid arthritis, ulcerative colitis, uveitis, multiple sclerosis and some forms of cancer.

Standard drug therapy for inflammatory-mediated diseases and trauma include steroids and non-steroidal anti-inflammatory agents (NSAIDs). Both classes of drugs offer temporary, symptomatic relief from swelling, inflammation and accompanying pain without treating the underlying condition. These drugs may also be immunosuppressive and cause dangerous side effects. The conscientious physician must weigh the benefits and long-term risks associated with the use of NSAIDs, especially in cases of rheumatoid arthritis. If left untreated, the inflammatory process itself can lead to limitation of joint function and destruction of bone, cartilage and articular structures.

NSAIDs are among the most widely prescribed drugs for rheumatoid arthritis and other inflammatory joint conditions. Their effects are mediated through inhibition of the biosynthesis of prostaglandins. They work by irreversibly blocking cyclooxygenase, the enzyme which catalyses the reactions of arachidonic acid to endoperoxide compounds. The neurological and gastrointestinal side effects of these agents have been reviewed in considerable detail. All of the NSAIDs, with the exception of Cytotec, inhibit prostaglandin El, a local hormone responsible for gastric mucosai cytoprotection. A common side effect from these medications is gastric ulcers. More serious adverse reactions such as blood dyscrasias, kidney damage and cardiovascular effects have been noted. Most physicians rotate among the ten most widely prescribed NSAIDs, as soon as one causes side effects or stops working.

The search for a physiologic agent that offers anti-inflammatory properties without causing side effects may have ended with the discovery of the Serratia peptidase (SP) enzyme. This anti-inflammatory agent is in wide clinical use throughout Europe and Asia as a viable alternative to salicylates, ibuprofen (sold as an OTC in the U.S.) and the more potent NSAIDs. Unlike these drugs, SP is a naturally occurring, physiologic agent with no inhibitory effects on prostaglandins and devoid of gastrointestinal side effects.

SP is an anti-inflammatory, proteolytic enzyme isolated from the microorganism, Serratia El5. This enzyme is naturally present in the silkworm intestine and is processed commercially today through fermentation. This immunologically active enzyme is completely bound to the alpha 2 macroglobulin in biological fluids. Histologic studies reveal powerful anti-inflammatory effects of this naturally occurring enzyme.

The silkworm has a symbiotic relationship with the Serratia microorganisms in its intestines. The enzymes secreted by the bacteria in silkworm intestines have a specific affinity to avital tissue and have no detrimental effect on the host's living cells. By dissolving a small hole in the ~ silkworm's protective cocoon (avital tissue), the winged creature is able to emerge and fly away. The discovery of this unique biological phenomenon led researchers to study clinical applications of the SP enzyme in man. In addition to its widespread use in arthritis, fibrocystic breast disease and carpal tunnel syndrome, researchers in Germany have used SP for atherosclerosis. SP helps to digest atherosclerotic plaque without harming the healthy cells lining Z the arterial wall. Today, researchers consider atherosclerosis an inflammatory condition similar to other degenerative diseases. Some immunologists are even categorizing atherosclerosis as a benign tumor. Hardening and narrowing of the arterial wall is a cumulative result of microscopic trauma; inflammation occurs in the presence of oxidized lipids. SP doesn't interfere with the synthesis of cholesterol in the body, but helps clear avital tissue from the arterial wall. It is important to note that cholesterol in its pure state is an antioxidant and a necessary component of the major organ systems in the body. The use of medications, which block cholesterol biosynthesis, may eventually damage the liver and compromise anti-oxidant status of the eyes, lungs and other soft tissues.

While studies with Serrapeptase in the treatment of coronary artery disease are relatively new, a wealth of information exists regarding its anti-inflammatory properties. SP has been used as an anti-inflammatory agent in the treatment of chronic sinusitis, to improve the elimination of bronchopulmonary secretions, traumatic injury (e.g. sprains and torn ligaments), post-operative inflammation and to facilitate the therapeutic effect of antibiotics in the treatment of infections. In the urological field, SP has been used successfully for cystitis and epididymitis.

SP has been admitted as a standard treatment in Germany and other European countries for the treatment of inflammatory and traumatic swellings. In one double-blind study of SP conducted by Esch et al at the German State Hospital in UIm, 66 patients with fresh rupture of the lateral ligament treated surgically were divided in three randomized groups. In the group receiving the test substance, the swelling had decreased by 50% on the third post-operative day, while in the other two control groups (elevation of the leg, bed rest, with or without the application of ice), no reduction in swelling had occurred at that time. The difference was of major statistical significance. Decreasing pain correlated for the most part with the reduction in swelling. The patients receiving SP became pain-free more rapidly than the control groups. By the 10th day, all patients were free of pain in the SP-treated group. The therapeutic daily dose was 1-2 tablets (5 mg) 3 times daily. In another double-blind study, the anti-inflammatory enzyme, SP, was evaluated in a group of 70 patients with evidence of cystic breast disease. These patients were randomly divided into a treatment group and a placebo group. SP was noted to be superior to placebo for improvement of breast pain, breast swelling and induration with 85.7% of the patients receiving SP reporting moderate to marked improvement. No adverse reactions were reported with the use of SP. The use of enzymes with fibrinolytic, proteolytic and anti-edemic activities for the treatment of inflammatory conditions of the ear, nose and throat has gained increasing support in recent years.

In a third double-blind study, 193 subjects suffering from acute or chronic ear, nose or throat disorders were evaluated. Treatment with SP lasted 7-8 days, two 5 mg tabs, t.i.d. After 3-4 days treatment, significant symptom regression was observed in the SP-treated group, while this was not noted in the control group. Patients suffering from laryngitis, catarrhal rhinopharyngitis and sinusitis noted markedly rapid improvement. The physicians' assessments of efficacy of treatment were excellent or good for 97.3% of patients treated with SP compared with only 21.9% of those treated with placebo. In a similar study of chronic bronchitis, conducted by a team of otolaryngolosits, the SP-treated group showed excellent results compared with the placebo group in the improvement of loosening sputum, frequency of cough and expectoration. Other improvements included the posterior nasal hydro rhea and rhinos enosis. The administration of SP reduces the viscosity of the nasal mucus to a level at which maximal transport can be achieved. It has also been demonstrated that the simultaneous use of the peptidase and an antibiotic results in increased concentrations of the antibiotic at the site of the infection.

The mechanisms of action of SP, at the sites of various inflammatory processes consist fundamentally of a reduction of the exudative phenomena and an inhibition of the release of the inflammatory mediators. This peptidase induces fragmentation of fibrinose aggregates and reduces the viscosity of exudates, thus facilitating drainage of these products of the inflammatory response and thereby promoting the tissue repair process. Studies suggest that SP has a modulatory effect on specific acute phase proteins that are involved in the inflammatory process. This is substantiated by a report of significant reductions in C3 and C4 complement, increases in opsonizing protein and reductions in concentrations of haptoglobulin, which is a scavenger protein that inhibits lysosomal protease. Carpal tunnel syndrome is a form of musculol-igamentous strain caused by repetitive motion injury. Individuals who work at keyboard terminals are particularly susceptible to this condition. While surgery has been considered the first line treatment for carpal tunnel syndrome, recent studies reveal that the use of anti-inflammatory enzymes (e.g. SP and bromelain) in conjunction with vitamins B2 and B6 are also effective. The use of non-invasive, nutritional approaches to the treatment of this common condition will become more important as a generation of keyboard operators approach retirement. Several research groups have reported the intestinal absorption of SP. SP is well absorbed orally when formulated with an enteric coating. It is known that proteases and peptidases are only absorbed in the intestinal area. These enzymes are mobilized directly to the blood and are not easily detectible in urine. Other enzymes with structural similarities have been reported to be absorbed through the intestinal tract. Chymotrypsin is transported into the blood from the intestinal lumen. Horseradish peroxidase can cross the mucosal barrier of the intestine in a biologically and immunologically active form. Several studies have appeared so far which refer to the systemic effects of orally given proteases and peptidases (e.g. SP), such as repression of oedema and repression of blood vessel permeability induced by histamine or bradykinin. These enzymes also affect the kallikrein-kinin system and the complement system, thus modifying the inflammatory response. In vitro and in vivo studies reveal that SP has a specific, anti-inflammatory effect, superior to that of other proteolytic enzymes. A review of the scientific literature, including a series of controlled, clinical trials with large patient groups, suggests that Serrapeptase is useful for a broad range of inflammatory conditions. If one considers the fact that anti-inflammatory agents are among the most widely prescribed drugs, the use of a safe, proteolytic enzyme such as SP would be a welcome addition to the physician's armamentarium of physiologic agents.

References:

Serrapeptase references:

l. Kee WH. Tan SL, Lee V. Salmon YM. The treatment of breast engorgement with Serrapeptase (Danzen): a random ized double-blind controlled trial. Singapore Med J. 1989:30(1):48-54.

2. M izukoshi, D. et al. A double-blind clinical study of serrapeptase in the treatment of chronic sinusitis. Igaku Ayrni 109:50-62.1979.

3. Carratu, L. et al. Physio-chemical and rheological research on mucolytic activity of serrapeptase in chronic broncho-pneumopathies. Curr. Ther. Res. 28(6):937-951. 1980.

4. Braga, P.C. et al. Effects of serrapeptase on muco-ciliary clearance in patients with chronic bronchitis. Curr. Ther. Res. 29(5):738-744,1981.

5. Mazzonie, A. et al. Evaluation of serrapeptase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind randomized trial versus placebo. J. int. Med. Res. 18(5):379-388,1990.

6. Kakinumu, A. et al. Regression of fibrinolysis in scalded rats by administration of serrapeptase. Biochem. Pharmacol. 31:2861-2866,1982.

7. Marly, M. Enzymotherapie anti-inflammatoire a l'aide de la serrapeptase: resultats cliniques en traumatologie et en ORL. C RTherapeut. 3:9-19,1985.

8. Odagiri, J. et al. Clinical applications of serrapeptase in sinusitis. Med. Consult. New Remedy 6:201-209, 1979.

9. Yamazaki, J. et al. Anti-inflammatory activity of TSP, a protease produced by a strain of Serratia. Folia Pharmacol. Japon. 6^302-314,1967.

I0. Harad~, Y. Clinical efficacy of serrapeptase on buccal swelling after radical operation for chronic sinusitis. Igaku Ayumi 123:768-778.1982.

11. Matsudo, A. et at. Effect of serrapeptase (Danzen) on inflammatory edema following operation for thyropid disease. Med. Consult. New Remedy 18:171-175, 1981.

12. Fujitani, T. et al. Effect of anti-inflammatory agent on transfer of antibiotics to the maxillary sinus mucosa in chronic sinusitis. Otorhinolaryngol. Clin. North Am. 66:557-565. 1976.

13. Tago. T. and Mitsui, S. Effects of serrapeptase in dissolution of sputum, especially in patients with bronchial asthma. Jap. Clin. Exp. Med. 49:222-228, 1972.

14. Mazzonie, A. et al. Evaluation of serrapeptase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind randomized trial versus placebo. J. int. Med. Res. 18(5):379-388,1990.

15. Kase, Y. et al. A new method for evaluating mucolytic expectorant activity and its application. II. Application to two proteolytic enzymes, serrapeptase and seaprose. Arzneimittelforschung 32:374-378,1982.

16. Marriott, C. Modification of the rheoloaical properties of mucus by drugs. Adv. Exp. Med. Biol. 144^75-84, 1982.

17. Majima. Y. et al. Effects of orally administered drugs on dynamic viscoelasticity of human nasal mucus. Am. Rev. Respit. Dis. 141:79-83.1990.

18. Miyata, K. Intestinal absorption of serrapeptase. J ApplBiochem. 1980:2:111-16.

19. Aso T. et al. Breast engorgement and its treatment: Clinical effects of Danzen (serrapeptase) an anti-inflammatory enzyme preparation. The world of Obstetrics and Gynecology (Japanese). 1981:33:371-9.

20. Esch PM, Gemgross H. Fabian A. Reduction of postoperative swelling. Objective measurement of swelling of the upper ankle joint in treatment with serrapeptase-a prospective study (German). FortschrMed. 1989;107(4):67-8, 71-2.

21. Majima Y, lnagaki M, Hirata K. Takeuchi K, M orishita A, Sakakura Y. The effect of an orally administered proteolytic enzyme on the elasticity and viscosity of nasal mucus. Arch Otorhinolaryngol. 1988;244(6):355-9.

22. Selan L, Berlutti F, Passariello C. Comodi-Ballanti MR, Thaller MC. Proteolytic enzymes: a new treatment strategy for prosthetic infections? Antimicrob Agents Cheroother. 1993; 37(12):2618-21.

23. Koyama A, Mori J, Tokuda H, Waku M, Anno H, Katayama T, Murakami K, Komatsu H, Hirata M, Arai T, et al. Augmentation by serrapeptase of tissue permeation by cefotiam (Japanese). Jpn JAntibiot. 1986; 39(3):761-

Studies and Technical Information

Serrapeptase - Scientific Background of the Most Potent Proteolytic Enzyme

Inflammatory Response

The Inflammatory Response is normally an important mechanism for protecting the body from attack by invading organisms, faulty cells and trauma. When the immune system becomes dysfunctional, it loses its ability to differentiate between innocuous and potentially dangerous substances. This dysfunction results in a wide array of autoimmune diseases such as rheumatoid arthritis, ulcerative colitis, allergies, psoriasis, uveitis, multiple sclerosis and some forms of cancer.

In spite of the huge range of successful enzyme studies showing safety and effectiveness, the standard therapy for inflammatory-mediated diseases and trauma include drugs such as steroids and non-steroidal anti-inflammatory agents (NSAIDs). These classes of drugs do in most cases offer temporary, symptomatic relief from swelling, inflammation and accompanying pain, but without treating the underlying condition.

Drugs

The drugs used to control the inflammatory response may be immunosuppressive and cause dangerous side effects. The benefits and long-term risks associated with the use of NSAIDs, especially in cases of rheumatoid arthritis, need to be weighed very carefully. If not successfully treated, the inflammatory process itself can lead to limitation of joint function and destruction of bone, cartilage and articular structures.

NSAIDs

NSAIDs are one of the most widely prescribed drugs for rheumatoid arthritis and other inflammatory joint conditions. They inhibit the biosynthesis of prostaglandins by irreversibly blocking cyclooxygenase, the enzyme which catalyses the reactions of arachidonic acid to endoperoxide compounds.

The Side Effects

The neurological and gastrointestinal side effects of these agents have been reviewed in considerable detail. All of the NSAIDs, with the exception of Cytotec, inhibit prostaglandin El, a local hormone responsible for gastric mucosal cytoprotection. A common side effect from these medications is gastric ulcers. More serious adverse reactions such as blood dyscrasias, kidney damage and cardiovascular effects have been noted. Most physicians rotate among the ten most widely prescribed NSAIDs, as soon as one causes side effects or stops working.

The Enzyme Alternative

The search for a superior enzyme that offers safe but powerful anti-inflammatory properties, thus averting the terrible side effects, ended when Serratia peptidase (Serrapeptase) enzyme was discovered in the early 70's. Serrapeptase is now in wide clinical use throughout Europe and Asia as a viable alternative to salicylates, ibuprofen (sold as an OTC in the U.S.) and the more potent NSAIDs. Serrapeptase is an anti-inflammatory, proteolytic enzyme isolated from the microorganism, Serratia E15 and has no inhibitory effects on prostaglandins, is devoid of gastrointestinal side effects and offers a sensible alternative.

Serrapeptase the Enzyme

Serrapeptase is processed commercially in the laboratory through fermentation. It was originally found in the silkworm where it is naturally present in its intestine. This immunologically active enzyme is completely bound to the alpha 2 macroglobulin in biological fluids. Histologic studies reveal powerful anti-inflammatory effects of this naturally occurring enzyme. The silkworm has a special relationship with the Serratia E15 microorganisms in its intestines. The enzymes secreted by the bacteria in silkworm intestines have the ability to dissolve avital tissue, but have no detrimental effect on the host's living cells. Thus by dissolving the silkworm's protective cocoon (avital tissue), the winged creature is able to emerge and fly away.

Wide Range of Applications

The discovery of this unique biological phenomenon led researchers to study clinical applications of the Serrapeptase enzyme in man. In addition to its widespread use in:

Arthritis
Fibrocystic breast disease
Carpal tunnel syndrome
Atherosclerosis

Researchers in Germany have used Serrapeptase for atherosclerosis to digest atherosclerotic plaque without harming the healthy cells lining the arterial wall.

Chronic Inflammation

Today, researchers consider atherosclerosis an inflammatory condition (similar to many other degenerative diseases whose cause is identified as chronic inflammation). Some immunologists are even categorizing atherosclerosis as a benign tumour. Hardening and narrowing of the arterial wall is a cumulative result of microscopic trauma; inflammation occurs in the presence of oxidized lipids. Serrapeptase doesn't interfere with the synthesis of cholesterol in the body, but acts as an anti-inflammatory and helps clear avital tissue from the arterial wall. It is important to note that cholesterol in its pure state is an antioxidant and a necessary component of the major organ and hormonal systems in the body. The use of medications, which block cholesterol biosynthesis, may eventually damage the liver and compromise anti-oxidant status of the eyes, lungs and other soft tissues.

Powerful Anti-Inflammatory

A wealth of information exists regarding its anti-inflammatory properties. Serrapeptase has been used as an anti-inflammatory agent in the treatment of:

Chronic sinusitis
To improve the elimination of bronchopulmonary secretions
Traumatic injury (e.g. sprains and torn ligaments)
Post-operative inflammation
To facilitate the therapeutic effect of antibiotics in the treatment of infections
Cystitis and epididymitis

Standard Treatment In Europe

Serrapeptase has been admitted as a standard treatment in Germany and other European countries for the treatment of inflammatory and traumatic swellings. In one double-blind study of Serrapeptase conducted by Esch et al at the German State Hospital in UIm, 66 patients with fresh rupture of the lateral ligament treated surgically were divided in three randomised groups. In the group receiving the test substance, the swelling had decreased by 50% on the third post-operative day, while in the other two control groups (elevation of the leg, bed rest, with or without the application of ice), no reduction in swelling had occurred at that time. The difference was of major statistical significance. Decreasing pain correlated for the most part with the reduction in swelling. The patients receiving Serrapeptase became pain-free more rapidly than the control groups. By the 10th day, all patients were free of pain in the Serrapeptase-treated group. The therapeutic daily dose was 1-2 tablets (5 mg) 3 times daily.

Cystic Breast Disease

In another double-blind study, the anti-inflammatory enzyme, Serrapeptase, was evaluated in a group of 70 patients with evidence of cystic breast disease. These patients were randomly divided into a treatment group and a placebo group. Serrapeptase was noted to be superior to placebo for improvement of breast pain, breast swelling and induration, with 85.7% of the patients receiving Serrapeptase reporting moderate to marked improvement. No adverse reactions were reported with the use of Serrapeptase. The use of enzymes with fibrinolytic, proteolytic and anti-edemic activities for the treatment of inflammatory conditions of the ear, nose and throat has gained increasing support in recent years.

ENT Success

In a third double-blind study, 193 subjects suffering from acute or chronic ear, nose or throat disorders were evaluated. Treatment with Serrapeptase lasted 7-8 days taking 5mg tablets. After 3-4 days treatment, significant symptom regression was observed in the Serrapeptase-treated group, while this was not noted in the control group. Patients suffering from laryngitis, catarrhal rhinopharyngitis and sinusitis noted markedly rapid improvement. The physicians' assessments of efficacy of treatment were excellent or good for 97.3% of patients treated with Serrapeptase compared with only 21.9% of those treated with placebo. In a similar study of chronic bronchitis, conducted by a team of otolaryngologists, the Serrapeptase-treated group showed excellent results compared with the placebo group in the improvement of loosening sputum, frequency of cough and expectoration. Other improvements included the posterior nasal hydro rhea and rhinostenosis. The administration of Serrapeptase reduces the viscosity of the nasal mucus to a level at which maximal transport can be achieved. It has also been demonstrated that the simultaneous use of the peptidase and an antibiotic results in increased concentrations of the antibiotic at the site of the infection.

The mechanisms of action of Serrapeptase, at the sites of various inflammatory processes consist fundamentally of a reduction of the exudative phenomena and an inhibition of the release of the inflammatory mediators. This peptidase induces fragmentation of fibrinose aggregates and reduces the viscosity of exudates, thus facilitating drainage of these products of the inflammatory response and thereby promoting the tissue repair process. Studies suggest that Serrapeptase has a modulatory effect on specific acute phase proteins that are involved in the inflammatory process. This is substantiated by a report of significant reductions in C3 and C4 complement, increases in opsonizing protein and reductions in concentrations of haptoglobulin, which is a scavenger protein that inhibits lysosomal protease.

Carpal Tunnel RSI

Carpal tunnel syndrome is a form of musculo-ligamentous strain caused by repetitive motion injury. Individuals who work at keyboard terminals are particularly susceptible to this condition. While surgery has been considered the first line treatment for carpal tunnel syndrome, recent studies reveal that the use of anti-inflammatory enzymes (e.g. Serrapeptase and bromelain), in conjunction with vitamins B2 and B6, is also effective. The use of non-invasive, nutritional approaches to the treatment of this common condition will become more important as a generation of keyboard operators approach retirement.

Superior Effects

In vitro and in vivo studies reveal that Serrapeptase has a specific, anti-inflammatory effect, superior to that of other proteolytic enzymes. A review of the scientific literature, including a series of controlled, clinical trials with large patient groups, suggests that Serrapeptase is useful for a broad range of inflammatory conditions. If one considers the fact that anti-inflammatory agents are among the most widely prescribed drugs, the use of a safe, proteolytic enzyme such as Serrapeptase would be a welcome addition to the physician's armamentarium of physiologic agents.

Serrapeptase References:

1) Kee WH. Tan SL, Lee V. Salmon YM. The treatment of breast engorgement with Serrapeptase: a randomised double blind controlled trial. Singapore Med J. 1989:30(1): 48-54.

2) Mizukoshi, D. et al. A double blind clinical study of Serrapeptase in the treatment of chronic sinusitis. Igaku Ayrni 109:50-62.1979.

3) Carratu, L. et al. Physio-chemical and rheological research on mucolytic activity of Serrapeptase in chronic broncho-pneumopathies. Curr. Ther. Res. 28(6): 937-951. 1980.

4) Braga, P.C. et al. Effects of Serrapeptase on muco-ciliary clearance in patients with chronic bronchitis. Curr. Ther. Res. 29(5): 738-744,1981.

5) Mazzonie, A. et al. Evaluation of Serrapeptase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double blind randomised trial versus placebo. J. Int. Med. Res. 18(5): 379-388,1990.

6) Kakinumu, A. et al. Regression of fibrinolysis in scalded rats by administration of Serrapeptase. Biochem. Pharmacol. 31:2861-2866,1982.

7) Marly, M. Enzymotherapie anti-inflammatoire a l'aide de la Serrapeptase: resultats cliniques en traumatologie et en ORL. C RTherapeut. 3:9-19,1985.

8) Odagiri, J. et al. Clinical applications of Serrapeptase in sinusitis. Med. Consult. New Remedy 6:201-209, 1979.

9) Yamazaki, J. et al. Anti-inflammatory activity of Serrapeptase, a protease produced by a strain of Serratia. Folia Pharmacol. Japon. 6^302-314,1967.

10) Harad, Y. Clinical efficacy of Serrapeptase on buccal swelling after radical operation for chronic sinusitis. Igaku Ayumi 123:768-778.1982.

11) Matsudo, A. et at. Effect of Serrapeptase on inflammatory oedema following operation for thyropid disease. Med. Consult. New Remedy 18:171-175, 1981.

12) Fujitani, T. et al. Effect of anti-inflammatory agent on transfer of antibiotics to the maxillary sinus mucosa in chronic sinusitis. Otorhinolaryngol. Clin. North Am. 66:557-565. 1976.

13) Tago. T. and Mitsui, S. Effects of Serrapeptase in dissolution of sputum, especially in patients with bronchial asthma. Jap. Clin. Exp. Med. 49:222-228, 1972.

14) Mazzonie, A. et al. Evaluation of Serrapeptase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double blind randomised trial versus placebo. J. int. Med. Res. 18(5): 379-388,1990.

15) Kase, Y. et al. A new method for evaluating mucolytic expectorant activity and its application. II. Application to two proteolytic enzymes, Serrapeptase and seaprose. Arzneimittelforschung 32:374-378,1982.

16) Marriott, C. Modification of the rheoloaical properties of mucus by drugs. Adv. Exp. Med. Biol. 144^75-84, 1982.

17) Majima. Y. et al. Effects of orally administered drugs on dynamic viscoelasticity of human nasal mucus. Am. Rev. Respit. Dis. 141:79-83.1990.

18) Miyata, K. Intestinal absorption of Serrapeptase. J ApplBiochem. 1980:2:111-16.

19) Aso T. et al. Breast engorgement and its treatment: Clinical effects of (Serrapeptase) an anti-inflammatory enzyme preparation. The world of Obstetrics and Gynaecology (Japanese). 1981:33:371-9.

20) Esch PM, Gemgross H. Fabian A. Reduction of postoperative swelling. Objective measurement of swelling of the upper ankle joints in treatment with Serrapeptase a prospective study (German). FortschrMed. 1989; 107(4): 67-8, 71-2.

21) Majima Y, lnagaki M, Hirata K. Takeuchi K, M orishita A, Sakakura Y. The effect of an orally administered proteolytic enzyme on the elasticity and viscosity of nasal mucus. Arch Otorhinolaryngol. 1988; 244(6):355-9.

22) Selan L, Berlutti F, Passariello C. Comodi-Ballanti MR, Thaller MC. Proteolytic enzymes: a new treatment strategy for prosthetic infections? Antimicrob Agents Cheroother. 1993; 37(12): 2618-21.

23) Koyama A, Mori J, Tokuda H, Waku M, Anno H, Katayama T, Murakami K, Komatsu H, Hirata M, Arai T, et al. Augmentation by Serrapeptase of tissue permeation by cefotiam (Japanese). Jpn JAntibiot. 1986; 39(3): 761-71.

TESTIMONIALS

Adhesions

'Within three weeks, I felt relief'

Since September 2006, I suffered with abdominal adhesions and had to take a prescription three times a day, all with no results. I tried Serrapeptase capsules, and within three weeks, I felt relief. I am improved 85% to 90%. It also helped with my varicose veins.

Date: 2/22/07
Country: USA

Initials: K.F.

Animal Treatment

'they have all now put their horses, dogs & husbands on Serrapeptase.'

Ruth called very upset as her 26 year old mare was so chronically lame with arthritis that 3 vets had recommend that she be put to sleep. We recommend that she try SerraPet, as she had tried everything else. We put Walnut on 12 tablets a day and to keep her on that until Ruth noticed an improvement then to drop the dosage to 8 a day. 18 months down the line Ruth and Walnut are back riding round the village and thrilled, Ruth keeps walnut on a maintenance dosage of 4 tablets a day. The other owners on the livery yard where Walnut has lived for the last 17 years were also impressed with Walnut's recovery that they have all now put their horses, dogs and husbands on Serrapeptase.

Ruth - Kelso, UK

'I used Serrapeptase on my horse.'

"This is a truly remarkable recovery, and I am absolutely delighted."

In your newsletter, you have asked for feedback about Serrapeptase. I am delighted to give you mine.

I used Serrapeptase on my horse, which sustained a severe tendon injury in April 2003. By June a scan showed that he had a chronic tendonitis with much scar tissue formed, both on the tendons, in the tendon sheaths and in the surrounding ligaments. The prognosis was poor; ?moderate to guarded for anything more than light hacking' said the report.

I had no idea about dose, so had to make an educated guess! I fed him 10 tablets of Serrapeptase a day for 6 weeks, then 6 a day for 2 months, then 3 a day for a further 2 months. He has just been re-scanned (November 2003). To my delight, the scan showed almost a full recovery. There is minimal scarring on the tendons, and none in the tendon sheaths or ligaments. He is expected to get back to full work now.

I can now bring him back into work. I will increase the work slowly over a period of 2 -3 months, and continue on a maintenance dose of Serrapeptase (2 a day) for a while.

This is a truly remarkable recovery, and I am absolutely delighted.

I will be spreading the word!

Liz Hayden

The Vet has said he is a walking miracle!!

Hi Robert,

I just wanted to let you know the success we have had with our dog taking Serrapeptase.

Approx. 9 weeks ago he was diagnosed with a sizeable bood clot that was affecting the bood supply to his rear legs, so much so that he went onto 3 legs as his left leg was very painful and eventually did not want to walk.

The scan that we had confirmed the position and size of the clot and that he did not have a pulse in either leg. He was given about a week to live.
I started him on Serrapeptase double strenght 3 times a day and each day he has slowley got better and better. Approx. 1 month ago he went for his check up and the vet informed me that his pulse had returned in his right leg and just two weeks later we returned to the vet to be told that he now has a pulse in both legs.

He is now almost back to his old self and walking a full perimeter of our park and enjoys chasing his ball again which for us is fantastic news.

All of this I am sure is down to the Serrapeptase that we have given him....even the vet has said he is a walking miracle!!

Country: USA

Clare Jeffries

'the dog had immediate results.'

We have a 14-year-old arthritic dog that could hardly walk. As he got older, he was getting much worse. We came across Serrepeptase, and to our great relief, the dog had immediate results. It has now stopped hurting, he is able to sleep much more comfortably, and he is generally more relaxed.

Yours faithfully,

A.H., USA

Writer Jenny Pulling interviews John Hopwood

Proof that the effects of complementary medicine and supplements such as serrapeptase are autosuggestion can be ruled out when it comes to animals. They have no conception of the placebo effect. Treat a dog or cat or, indeed, any other animal and it either ?works' or it doesn't. and, according to John Hopwood it's certainly worked with his lurcher dog who was suffering from severe colitis, causing constant diarrhoea.

Says John: "This lurcher came to us as a stray so we're not sure how old he is. We're great dog lovers and give our animals the best so we put him on organic meat. Whether it was a coincidence, we don't know, but very soon after that he developed colitis and it was very bad for a long time. So we knocked off the organic meat and decided to try serrapeptase. I'd already been taking it myself for my heart problem. It certainly worked and, although he'd got very thin he began to put on weight again. We've now established a regime including feeding him Chappie which seems to suit him.

The HOPWOOD's' lurcher is on two capsules a day but while John was in hospital his wife noticed signs of the problem recurring. The couple have decided to ?up the dose'

Meanwhile, John continues to recommend serrapeptase. One friend was due for a triple heart bypass an operation he is reluctant to undergo. As I write, he is giving serrapeptase a chance, hoping it will clear the arteries, one of the properties of this secret of the silkworms.

Jenny Pulling

I noticed a difference in him in a matter of days.

My dog and I have been taking Serrapeptase for about 4 months now. Bruno, our 10 year old collie, has been getting progressively worse from the effects of arthritis in his front and back legs. Some days he would have a very hard time getting up or would almost fall back down after standing up. A once very active part of the family had gotten very lethargic and tired looking in less than a couple of years. I began giving him a Serrapeptase in his treats when I began taking it. I noticed a difference in him in a matter of days. I immediately noticed he had a much easier time getting up and down off of the floor and he started jumping into my lap, which he hadn't done in quite a while. He even got to feeling so much better, that on weekends, when we had a little more time to play with him, he would over do it a little and have a hard time getting moving on Monday morning again. We started giving him two in the morning and two in the evenings after more active days, and he's been doing great since.

Eric Oesterling

Cysts

'We were amazed by its power'

"We were amazed by its power in dispersing two cysts, one on her back and one on her breast"

The couple are spiritual healers and have helped many people with health problems in the course of their work. One of their clients is over 80 years old who suffered a stroke some time ago. The Joness' suggested she try Serrapeptase as an aid to clearing the arteries and sure enough her walking ability improved.

Mrs Jones adds: "We were amazed by its power in dispersing two cysts, one on her back and one on her breast After only three bottles of Serrapeptase the one on her back has completely disappeared while the one of her breast is shrinking. She says she feels wonderful!"

The Jones' have had their own positive experience with the silkworm's secret. About three years ago, Mr Jones had a bad fall. Conscious of his recent hip replacement he took the full impact on his left shoulder which left him in terrible pain.

Mrs Jones takes up the story: "We were going on a coach holiday to Slovenia when this pain really flared up. The doctor prescribed an anti inflammatory but the side effects were disastrous and my husband stopped taking them."

Returning to another doctor for a cortisone injection, Mr Jones was told that the problem was not in his shoulder but his arm. At that point, the couple read about Serrapeptase.

"I said to my husband, I'm going to send off for those; I'd rather have £60 less holiday money if you can be pain free. He started taking them 3 weeks before our holiday and the happy ending is that the pain went away and never came back. Now he can swing his arms above his head!"

Having proved for themselves the efficacy of Serrapeptase, Mr and Mrs Jones often suggest it to their clients. And Mrs Jones is an advocate of the low carbohydrate diet prescribed by Robert Redfern.

"It's brought my diabetic sugar levels back to normal," she smiles. "It's amazing!"

Mr and Mrs Jones - North Wales

'After using Serrapeptase I was healed. Thanks'

"I play volleyball and had developed cysts and inflammation. After using Serrapeptase I was healed. Thanks."

D.L. - Santa Clarita, CA

Mr and Mrs Jones' Cysts & Cardiovascular Disease

Mrs Jones adds: "We were amazed by its power in dispersing two cysts, one on her back and one on her breast. After only three bottles of Serrapeptase the one on her back has completely disappeared, while the one on her breast is shrinking. She says she feels wonderful!"

The Joneses have had their own positive experience with the silkworm's secret. About three years ago, Mr Jones had a bad fall. Conscious of his recent hip replacement, he took the full impact on his left shoulder, which left him in terrible pain.

Mrs Jones takes up the story: "We were going on a coach holiday to Slovenia when this pain really flared up. The doctor prescribed an anti inflammatory, but the side effects were disastrous and my husband stopped taking them."

Returning to another doctor for a cortisone injection, Mr Jones was told that the problem was not in his shoulder but his arm. At that point, the couple read about Serrapeptase.

"I said to my husband, I'm going to send off for those; I'd rather have £60 less holiday money if you can be pain free. He started taking them 3 weeks before our holiday and the happy ending is that the pain went away and never came back. Now he can swing his arms above his head!"

Having proved for themselves the efficacy of Serrapeptase, Mr and Mrs Jones often suggest it to their clients. And Mrs Jones is an advocate of the low carbohydrate diet prescribed by Robert Redfern. "It's brought my diabetic sugar levels back to normal," she smiles. "It's amazing!"

Mr and Mrs Jones - North Wales

'After 3-4 weeks of taking it the Cyst have totally gone.'

I had suffered with Cyst on my back for roughly 3-4 years. I had been to see my doctor who told me to leave them alone as there was nothing that could be done. I then heard about Serrapeptase and started to take it in the hope it would give me some relief. After 3-4 weeks of taking it the Cyst have totally gone. I cannot believe how it has worked for me. Another benefit to my life is that it has also reduced the occasional inflammation I suffer in my knees.

J.P. - AZ, USA

'Within three months the cyst had disappeared.'

"I feel as though I've been given an extra life!" says 64-year-old Dorothy Antrobus,

"I feel and look good and it's thanks to Serrapeptase. I swear by it."

Some while ago Dorothy had surgery on her knee and all seemed to go well. Then she began to experience a lot of pain and was told she had developed a cyst

"The hospital did a MRI scan and suggested they could operate again to drain the cyst. I didn't like the sound of that but I didn't know what else to do. I was in a terrible state couldn't even put my knee on the floor when I was doing my part time job in a shop. I couldn't walk and I love walking but worst of all I have a lovely horse and I'd begun to face up to the fact I might not be able to ride him again. I needed my knees

"One day someone came to the shop to test food sensitivities and suggested I try Serrapeptase. She'd heard wonderful results from it."

The rest is history. Within three months the cyst had disappeared.

"I was so impressed. Since then I have gone onto a maintenance dose of one capsule a day. I am riding my nine-year-old cob, walking, doing everything I want to do. It is absolutely amazing and must be due to Serrapeptase for I've taken nothing else. Of course the consultant will say it would have gone whatever you did because they are always so sceptical. Many doctors don't agree with complementary therapies but all I know is that I had a knee that looked as if it had two kneecaps and now it is normal.

"Serrapeptase also helped my varicose veins. I do a lot of standing in the shop and have had an operation. I knew it was working when someone asked me ?what are you taking Dot, you're running up and down stairs lie a three year old.'

"When I look back I think how awful it was going out to look at my horse in the field and thinking ?I've done all the hard work of showing and now when I could enjoy some hacking there's too much pressure on the knee and I can't do anything.

Serrapeptase has given me a new life. I think it is absolutely wonderful."

Dorothy Antrobus

My Doctor 'just shook his head in disbelief.'

Sylvia Burge astonished doctors when painful nodules on her colon disappeared following her decision to try serrapeptase. She had decided on private medical treatment when she realised something would have to be done about the nodules.

"The first time the doctor began to give me an examination but had to stop because he was hurting me. I heard about serrapeptase and thought I would give it a try. After three months I returned to the doctor and this time went through with the examination. He just shook his head in disbelief. I don't really know why you're here,' he said ?I can't find anything at all.'"

Sylvia had also suffered a constant and very bad sore throat and believes serrapeptase has also rid her of that.

Sylvia Burge

Emphysema

'I have Emphysema, but now feel like I did 30 years ago.'

Dear Staff, Thank you for the fast service. I'm not writing this to claim a freebie, but to say with Serrapeptase and Oxysorb, my life has changed beyond my wildest dreams! I have Emphysema, but now feel like I did 30 years ago. I have reduced my inhalers by 50% and could do with less. I felt today as if I was in a dream! Regards,

Tom Scally

Emphysema - Caroline Harvey

I'm Caroline Harvey a complementary therapist.

"The best result I have had was with a man who was 93 when I first saw him this was about 2 years ago.He was suffering from very bad emphysema to the extent he could hardly walk let alone go up stairs and was on oxygen 12 hours a day since he took Serrapeptase he has been able to lower his intake of oxygen by 50%. I saw him a few months ago he is now 95. He was going to the Health Centre on the treadmill and said he was looking for a new wife. He is taking minerals and vitamins as well but it is the Serrapeptase that has yielded best result lowering inflammation in the lungs.

Caroline Harvey

'I could hardly believe the improvement in his health.'

We were on a 3 week cruise and happened to meet one of the other passengers who was obviously in poor health. His lips were blue and his breathing laboured. When we got off to visit places he could hardly walk.

He was 72 years old and told us he suffered from asbestosis, emphysema and heart problems.

Having used Serrapeptase for all my family and friends, I just had to tell him about it. I happened to have a spare bottle with me, so I gave it to him.

He took 3 per day for the rest of the cruise, and even I could hardly believe the improvement in his health. By the end of the cruise, his lips were pink and he was able to do the full excursions.

I have spoken to him since and he has bought some himself and is now able to drive for the first time in a long time.

Mrs. Hardman

'It seems to have no bad side effects at all.'

When a recent respiratory test revealed a remarkable improvement in Mr Clarke's breathing capacity, medical staff were impressed and want to learn more about its properties.

"It is early days yet," says Joy, "we're going to wait until he sees the specialist next time. But my husband is certainly continuing to take serrapeptase. Unlike the steroids which affect the adrenal gland and cause depression, serrapeptase seems to have no bad side effects at all. Maybe in time we can get him off these other drugs. I know they're not good for you in the long term."

Mrs. and Mr. Clarke

Fibrocystic Breast Disease

'Serrapeptase is absolutely wonderful.'

Carole Dougall, interviewed by writer - Jenny Pulling

I called Carole Dougall at a busy moment in the Ki Clinic in Hexham. We had a brief conversation but you could tell from her tone she was absolutely delighted with Serrapeptase.

"I'm on my fourth bottle but after only three bottles all the lumps in my breasts had disappeared. They used to be very lumpy and my fear was that if I was developing cancer I would never be able to tell the difference. Serrapeptase is absolutely wonderful."

Carole Dougall

'I am so grateful for this God send.'

"I no longer have the very painful walnut sized cyst in my breasts"

My husband and I have been taking this for about 2 months. My husband had been in the habit of taking Corcidin D (A cold and sinus med) almost every day for years for headaches due to sinus. He has also taken Tylenol like it is going out of style along with the cold medication. His usual dosage was 3 Tylenol along with 2 Coricidin D Since starting with Serrapeptase he has only taken 3-4 doses. We believe this is because of missed doses of serrapeptase.

I have been taking it for pain due to Arthritis, fibrous breast cysts, and adhesions from surgery. I no longer have the very painful walnut sized cyst in my breast. My pain from arthritis is maintained, and the adhesion from surgery no longer pulls and stings inside. I truly believe this product is worth mentioning to anyone who may suffer. I also give it to my dog Samson once a day for his arthritis. He doesn't wait at the stairs for me to carry him up or down and I can tell he is feeling better.

I am so grateful for this God send. I am telling all my friends and family.

Diane Nichols

Fibroids

Fibroids - Alicia McCalla

I just recently purchased the Serrapeptase with MSM and noticed a tremendous difference with my menstrual cycle. I have two small uterine fibroids and always have terrible cramps. This cycle, I had no pain and didn't realize that it had started. Amazing. I did some additional research and found that Serrapeptase mixed with Nattokinase has had lots of success with reducing uterine fibroids.

Alicia McCalla

Endometriosis and Fibroids

I suffered Endometriosis on the outside of my uterus, as well as several small fibroids located in my uterus. I had excessive bleeding for four years, with clots and uterine pain. My menses were lengthening to 10 days. I was eating only organic products and staying away from hormone injected foods, such as dairy and non free range meat. After I had an endometrial ablation done in November of 2005, they could not remove the fibroids or the endometriosis. So, in February of 2006, I started on Serrapeptase for a few months. The pain started decreasing almost within the first week! I finally went in October of 2006 for a vaginal partial hysterectomy, and afterward, I was told that there were no fibroids and my cervix and uterus were normal. As a result of taking the Serrapeptase in 2006, I was able to resume a fairly normal, activity-orientated type of lifestyle, without so much pain.

Date: Feb 6, 2007
Country: Canada

Initials: H.G.

Fibrosis of the Lung

Fibrosis - Mr. D. Irving

You'd imagine after 40 years working in his own shop Mr Irving would have been happy to retire. At 64 he'd sold his butchers shop and was looking forward to enjoying more time in his beautiful home town Port Patrick. But it wasn't long before he got bored and started looking around for a job. He was pleased when he found one in a local fish factory. But not long after that his problems began.

"I got terribly ill and one of my lungs collapsed," he says, "Fibrosis of the lung was diagnosed. I don't know how it developed. Maybe it was years of making sausages or the fact that using a pin boner in the fish factory creates dust, I don't know.

"I had to go to the doctor although I don't like taking orthodox drugs. It had got to the point where I had to sit in a chair and couldn't walk down to the harbour.

"My GP referred me on because he thought I should be receiving oxygen. It didn't help. I was just getting weaker and weaker I'd tried everything herbal but nothing was doing me any good.

"Then my wife heard about serrapeptase from someone in our local health shop. She contacted the company for more information and I started on my first course, last August. It sounds ridiculous but within three weeks I was walking again

"I'd been so sad about not being able to walk. We live in a lovely part of Scotland. Now I walk down to the harbour and if I get breathless my wife picks me up in a cab. I have gone back to gardening and having always done a lot of church work and I am back to that again.

"I'm a Christian but I think we also have to help ourselves. Serrapeptase is absolutely marvellous. I recommend it to all my friends."

Mr. D. Irving's Experience With Serrapeptase

Lung - Asbestosis, Miners and Farmers

Asbestosis - Mrs. Hardman

He was 72 years old and told us he suffered from asbestosis, emphysema and heart problems.

Having used Serrapeptase for all my family and friends, I just had to tell him about it. I happened to have a spare bottle with me, so I gave it to him.

He took 3 per day for the rest of the cruise, and even I could hardly believe the improvement in his health. By the end of the cruise, his lips were pink and he was able to do the full excursions.

I have spoken to him since and he has bought some himself and is now able to drive for the first time in a long time.

Mrs Hardman

'Without it he just wouldn't be here.'

"I can't tell you what a difference those tablets have made to this household," smiles Mrs Maher. "They've kept the disease at bay. Without them he just wouldn't be here."

It is always distressing to see a loved one suffering as Mrs Maher found out when she learned her father was suffering from asbestosis. About three years ago, he was taken into hospital to be diagnosed with this horrible lung condition. Mrs Maher never believed he would come out but finally he was discharged.

As she recalls: "He was in such a bad way he could not walk from the front door into the driveway. I was at my wits end as to what to do, then a friend gave me the Serrapeptase website which impressed me. My father promised to take it seriously. The results were almost immediate. This was on a Monday and by the following Saturday morning he seemed to have regained some of the confidence he had lost in hospital. I suggested giving him a lift to the local shops and he said ?no, I am going to walk' It took him some time but he got there.

When Mrs Maher spoke to me her father had gone down to the town centre and managed to ?toddle round the shops' and meet a few friends. Another benefit is that the dry flaky skin and dandruff the 74-year-old developed following continual use of a Nebulizer has also cleared up.

"I can't tell you what a difference those tablets have made to this household," smiles Mrs Maher. "They've kept the disease at bay. Without them he just wouldn't be here."

Margaret Maher

Lung: Chronic Cough

'Persistent Cough & Colds made her life a misery.'

"It also helped another friend with severe cystitis. It is amazing that such a simple remedy should be so effective"

Mrs T's persistent cough and colds made her life a misery. She just couldn't shake them off. Preferring ?natural' medicines wherever possible she favours homeopathy and bio salts.

"Orthodox drugs often have unwanted side effects," she says. "That's why I was interested when someone told me about Serrapeptase. To be honest I am delighted with it. If I have a cold or a chesty cough I find it's completely gone in a couple of days.

"I was interested to learn about its action in dissolving scar tissue and recommended it to a friend who had been suffering with the dreadful pain of sciatica for a long time. It also helped another friend with severe cystitis. It is amazing that such a simple remedy should be so effective."

S.T. Doncaster

'Shortness of Breath and 20 Years of Back Pain'

I first started ordering Serrapeptase for my neighbour. I am her Naturopathic Counselor. She had a cough that wouldn't go away, and one of the groups I am in recommended Serrapeptase. After taking 2 tablets 3 x a day of the 40,000IU capsules for about six weeks, her shortness of breath had lessened, her voice was back to normal, and her cough had subsided to just a little.

After doing much research on this product, I decided to buy a case. I gave some to my brother and his wife, my sister, and my son. I started taking 2 capsules 2 x a day of the 40,000IU the first part of March 2007. I did not have any real ailments that I was targeting, but, being a smoker, (I know I should quit), I realized the benefits it would bring. I had a constant pain in my back for over 20 years. It was something I just lived with, and never really took anything for it unless it got too unbearable. After taking Serrapeptase for about three weeks, I was talking to someone about it, and I realized I had no pain. Ever since that time, I have been pain free. This is probably the first time in my life that, no matter how hard I work (and I'm a hard worker), I am completely pain free all the time, and I feel great.

I am so amazed with this product that I talk to people all the time about it. Almost everyone I know could benefit from it one way or another. I now take 2 to 3 a day just for maintenance.

P.S. I didn't mention it earlier, but I'm in my 50's and feel like 30.

Date: 6/20/07

Country: USA

Initials: SD

Lung: COPD

Serrapeptase and COPD

Sheila Bushell, a pharmacist from London, who uses Serrapeptase herself, tells of a man in his 30's who was suffering from a severe lung condition, bronchiectasis, which made it difficult to clear mucus. He was prescribed antibiotics for 12 months, but his condition deteriorated to such as a degree that he could not travel to work and could only work part-time at home.

Sheila suggested he try Serrapeptase, so he asked his consultant, who ridiculed it and said his lungs were permanently damaged, and he would have to learn to live with it; a daunting prospect at his age! He decided to try it and took 4 SerraEzyme 80,000IU per day. He quickly began to improve and clear his lungs. After 2 weeks he felt so much better that he returned to his full time work.

Date: 11/29/07
Country: UK

Sheila Bushell, Pharmacist

Neuroma Fibroma

'I can hardly believe the result.'

Dear Robert,
About 18 years ago, I had vaccination shots for typhoid. I had a bad reaction and felt rough for a few days. I then noticed a pea sized lump at the site of the injection. This steadily grew to the size of a golf ball. It was extremely tender and painful to the touch. I couldn't even wear a jacket. The doctors eventually diagnosed it as a neuroma fibroma, a proliferation of nerve and fibres of the nerve sheath. They said there was nothing they could do as there was too much nerve involvement. I have had this lump for 18 years now and it has affected my life. If I roll onto it in bed, or if anyone brushes against my arm, or worst of all gives me a friendly slap, the terrible pain shoots through me like an electric shock. A few weeks ago, I heard about serrapeptase and contacted the helpline. I was advised to take 3 capsules, 3 times a day. I have now taken three bottles and I can hardly believe the result. The lump has shrunk by about a third and the pain is a lot less. I am absolutely delighted and looking forward to a complete removal of the problem.

Steve Clarke

Other Conditions

'It has greatly improved the quality of many of my patients' lives.'

Dr Simon Norton - Epsom Chiropractic Clinic

Dr Simon Norton who heads the Epsom Chiropractic Clinic is delighted with results. "It has greatly improved the quality of many of my patients' lives".

'Serrapeptase has improved my lung function significantly'

Just a line to thank you, most sincerely, for the very prompt attention given to my query and for putting my mind at rest.

I also wish to confirm that using Serrapeptase has improved my lung function significantly, reduced breathing problems at night by reducing the viscosity of nasal mucus thus enabling easy disposal, reduced hip, back and knee pains and seems to be helping my varicose veins and swollen ankles. I shall resume treatment at the rate of two capsules/day and confine the use of colloidal silver to the treatment of colds, coughs and general disinfection, as advised.

Thank you again for prompt attention.

Yours sincerely,

S.H.Rusinowski

Multiple Conditions - Brain Hollingworth

A long time friend of Robert Redfern, Brian Hollingworth looks back to his 60s when his friends Robert and Anne Redfern visited his home. He has certainly taken the couple's philosophy of good health naturally on board and particularly recommends Serrapeptase, Nattinokase/Serrapeptase Formula and Colloidal Silver.

"I had high blood pressure, all sorts wrong with me so I had to go to my doctor but told him I didn't want to be put on drugs. I talked to him about herbal medicine and he told me I knew more about it than he did. I haven't been back since. With Nattinokase/Serrapeptase Formula and Serrapeptase I've managed to sort my health problems out for myself."

Brian's employment history included a lot of heavy manual work and his joints have suffered.

"I can't do proper exercise, I am not allowed to go walk about as I've had three knee operations. I find Serrapeptase a wonderful anti-inflammatory. And I'm convinced it's keeping my arteries clear."

"I am so convinced I sent both Nattinokase/Serrapeptase Formula and Serrapeptase to a friend in Ireland. She'd had a serious aneurysm. The results have amazed her surgeon. After six months it had completely cleared."

"I've now got my wife onto these supplements. She had a thrombosis in her left leg due to varicose veins. We're in our 70s but feeling younger by the day."

Brain Hollingworth

Peyronies

Peyronies - RM

Dear Sirs,

I am 63 years of age and my wife is 20 years younger. We have an excellent sex life. I am healthy although my blood pressure was slightly high. I take ramipril tablets - 10g per day. Without any prior warning in Nov. 2005 I experienced an acute pain on obtaining an erection. The pain was so intense I could not complete the sex act. The next evening the same thing occurred. For the next few weeks the pain was intense and I then noticed a lump the size of a pea and I could also feel a thickening under the skin of my penis. I went to the doctor and he immediately said Peyronies and that nothing could be done. I then saw a specialist who said it may well revert back without treatment and that I should wait but take Vitamin E. I then sought help and eventually ordered Serrapeptase. I started taking 9 per day and within a week the pain had gone and I could feel the thickening inside the penis disappearing although I could still feel the lump like a pea. I am now on my 5th bottle and the thickening has definitely subsided. I do not have any pain and we have managed sex with little trouble. The one problem is that the penis bends slightly upwards but I have ordered a second supply of Serrapeptase and hopefully this will continue to improve the problem.

R.M.

Post Operative Trauma

Joanna Fenwick-Smith's Mother In Law

Like many serrapeptaste users Joanna recommends it with a missionary zeal. When her mother in law had an operation for melanoma on her leg the wound refused to heal. She began on serrapeptase and it ?immediately started to heal beautifully.'

Joanna Fenwick-Smith

Joanna Fenwick-Smith's Husband

Even a sceptic like her husband has had to admit it ?works.
Says Joanna: "He'd had an operation for a removal of a small mole on his back but the hole it left was huge. I could put my finger up to the first joint inside. He'd had instructions to keep it covered and return to the consultant in three months. But when I noticed the dressings were green I was alarmed. I persuaded him to take serrapeptase and the result was once again swift healing. He is now converted."

Joanna Fenwick-Smith

'my surgeon was flabbergasted at my quick recovery.'

First of all I would like to thank you for your excellent product. I used it last year as part of my recovery plan from surgery for a spinal lymphoma and my surgeon was flabbergasted (literally) at my quick recovery. I have also recommended it to my 76 year old father who tells me that it has transformed the pain in his arthritic knees.

Gerhart Knerer

Since taking Serrapeptase (my scar) has healed and flattened.

Talking to Mrs Temprell is inspirational. In spite of undergoing very invasive surgery over the past four years she told me:

"You have got to be positive. I am the eldest of six brothers and sisters and it seems I am being ill on behalf of all of them. But at least I know how to do something about it."

As is often the case, personal experience with illness and the limitations of orthodox medicine led her to research other routes and discover what works for her. Like many others she has chosen to take the ?complementary ' path.

It was 2002 when Mrs Temprell was diagnosed with breast cancer. Her treatment involved a mastectomy and later she had another operation to implant prosthesis. Everything began to go wrong after that.

"They had to change it in August 2004 because it was leaking; then they put in one that was too big and when I lay down it was pressing on my throat."

This was removed in 2005 and a smaller one implanted but that gave her a sense of constriction.

Mrs Temprell was already aware of Serrapeptase. She'd been taking it for the thickening of one of her lungs, caused she believes by increased fluid following the botched prosthesis operations. The Serrapeptase and Nattinokase Formula has also been a great help and she has been on it for six months.

"I became terrible terribly out of breath, I could feel this awful restriction with the slightest exertion," she says. "But look at me today I've been talking to you for a long time and I'm fine.

I can walk too, I am slowly getting there,"

She also found it gave relief from the congested feeling of the third prosthesis. . "It is just magic. I thought I had a little lump but it wasn't and now I can press it and the congestion has gone.

"I started on my first course last October. I take the capsules religiously, three in the morning and three at night. I've got the book and I've read it through and through so I know I am using it properly

"I also had a four-inch scar after my operations and it was very raised. Since I've been taking Serrapeptase it has healed and flattened. There is about three quarters of an inch left and it is going.

"I've got my husband onto Serrapeptase too. He suffers from varicose veins and his legs were always very swollen. If he banged his leg the injury wouldn't heal, some kind of ulcer I suppose. Every time he went to the doctor he was given a stocking and then water tablets to try to reduce the swelling. Since he's taken Serrapeptase and the Serrapeptase and Nattinokase Formula he has young man's legs the colour is still reddish but all the swelling has gone.

Mrs J Temprell

Mrs Cole on Post Operative Trauma

"We had a very good response for my father when he had post operative haemorrhaging. There was really extensive bruising from his groin to his foot so I put him on Serrapeptase. The results were amazing. It was clear within about a day.

It seems to work well as an anti-inflammatory and a dissolver of non-vital matter in the body such as the dead blood that was creating such bruising in my father's leg.
We've also had good results with problems like sports injuries sprains that kind of thing.", A dear friend who is a qualified Pilates and training instructor suffers from arthritis in her toes. At one time she continued to run ?through the pain' until she was forced to stop. Some tubs of Serrapeptase later she just keeps on running.

Mrs Cole

Scars & Lesions - Post Operative

Savita Bhandari is interviewed - Jenny Pulling

Take SAVITA BHANDARI owner and practitioner of Vita Health. At her clinic in Croydon she offers all kinds of therapies including nutrition and bio resonance.

Savita came across Serrapeptase while she was treating a woman client who had a spinal operation for misaligned disks at the age of 23, leaving her with a 15" scar.

"She is now 55 and when she first came to the clinic told me she has always been in pain. After such operations there is often a lot of scar tissue and adhesions and I gathered this was causing her acute pain.

I began to treat her with supplements and bio-resonance. It was quite distressing to watch her as she was obviously in such a lot of pain and although this improved it was not as much as I would have wanted.

One day Savita came across some literature on Serrapeptase and decided she would try it on her client.

"I have to say it is absolutely fantastic!" she says. "My client took Serrapeptase for 6 weeks at the rate of 3x3 3x3 3x2 3x2. After a month she said she felt marvellous and not long after that went on holiday with her husband and two children to Morocco where they did a lot of walking and climbing. Last year her daughter was getting married so my client was able to travel to Pakistan to buy wedding clothes.

She is on a maintenance dose now and gets a few aches and pains but only because she is so active.

"I think it is a marvellous product."

Savita Bhandari

FREQUENTLY ASKED QUESTIONS

Why do doctors not prescribe Serrapeptase if it is so good?
What successes have there been with cysts and adhesions on the ovaries?
Would Serrapeptase be useful in eliminating a goitre or uterine fibroids?
Wondering if Serrapeptase ever used for Peyronie's Disease (curvature of penis)?
I will be having ACL surgery and would like to use this enzyme in my recovery.
My husband has nasal polyps and is about to go into hospital for the third time to have them removed. Will this product help him?
As it is 2 years post-op, I do not have pain. Maybe a burning sensation if the scar tissue is massaged, but that's about it. Do you still think Serrapeptase is effective as the scar tissue is this old? If so, what doses should I be taking and how often?
I have abdominal scar tissue 2 years after a lipoplasty procedure. I heard that Serrapeptase could help "dissolve" internal scar tissue. Is there any truth to this?
I can understand internal scars (lesions and adhesions) but what about external scarring?
I wanted to know if Serrapeptase clears external scar tissue.
Will there be any drug interaction with my seizure medicine tegretol & lamictal?
I am on Warfarin, is it safe to take Serrapeptase?
Is Serrapeptase safe for use when taking blood pressure medication?
Will this conflict with any drugs I am taking or cause my blood to become to thin?
Can it be taken with other medication and do I need to inform my Doctor?
Can it be used on animals such as cat and dogs?
My son has Crohn's Disease, he is 10 years old can he take these tablets and how many?
If the tablets are enteric coated, does it not destroy that coating to chew the tablets - e.g. in the case of a child?
What is the Clinical usage of Serrapeptase in children, with dosage precautions and other relevant clinical information?
How long has Serrapeptase been in use?
Where can I purchase Serrapeptase? Can it be purchased in Australia? If not can it be imported into Australia?
My research indicates that Serrapeptase is destroyed by stomach acid and therefore needs to be enteric-coated. Do you have research that shows otherwise?
I have recently begun a supplement program, which includes 140 mg of Serrapeptase daily. This seems close to your max dosage of 150 mg for, for example, acute trauma. Is it safe to take 140 mg daily indefinitely? If not, what would you recommend as a max daily dose?
Does it thin the blood?
If the results tabulated are so beneficial to sufferers, why is this product so little known?
Who makes this product?
What is Serrapeptase?
Has it any side effects or can I take too many?
Why can it benefit so many different conditions?
Are there any animal products within your product?
You say suitable for vegetarians, yet I read that this comes from a silkworm? Does it or does it not?
How does Serrapeptase help sinusitis?
Can it get rid of my varicose veins completely?
Can this also help varicose veins?
Are you sure Serrapeptase is safe for cystic fibrosis?

Why do doctors not prescribe Serrapeptase if it is so good?
They do, in the better medical systems such as Germany and other countries with superior results compared to the UK and the USA. They have prescribed it for the last 25 years.
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What successes have there been with cysts and adhesions on the ovaries?
I can absolutely confirm that it will give fabulous results with 4-6 weeks. This is a common problem that it is used for. Take 3 x 3 on an empty stomach and reduce as symptom go.
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Would Serrapeptase be useful in eliminating a goitre or uterine fibroids?
I have had good reports on fibroids but none on goitre. I do believe however that they are almost the same problem that is the upsetting of the hormonal system caused by eating starchy carbohydrates. These are implicated in the majority of diseases. Taking Serrapeptase, nutritional supplements alongside a good nutritional program outlined on the web below or my book is I believe the perfect way to good health.
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Wondering if Serrapeptase ever used for Peyronie's Disease (curvature of penis)?
I have had good feedback. It works on the growth that causes it and should diminish with Serrapeptase.
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I will be having ACL surgery and would like to use this enzyme in my recovery.
Serrapeptase will certainly help in your post-op recovery.
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My husband has nasal polyps and is about to go into hospital for the third time to have them removed. Will this product help him?
It should do, it gets rid of other cysts. Start within 24 hours of any operation and so he can use them immediately he comes out to prevent the return of the polyps.
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As it is 2 years post-op, I do not have pain. Maybe a burning sensation if the scar tissue is massaged, but that's about it. Do you still think Serrapeptase is effective as the scar tissue is this old? If so, what doses should I be taking and how often?
It really depends upon your finances. I always recommend 3 x 3 to start with and then reduce each week as the symptoms reduce. When symptoms are gone take the lowest dose 1 x 2 per day.
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I have abdominal scar tissue 2 years after a lipoplasty procedure. I heard that Serrapeptase could help "dissolve" internal scar tissue. Is there any truth to this?
Yes it is a very effective and safe solution. It will take about 3 weeks to get rid of the discomfort and a further 3-6 weeks to make sure it they are completely clear.
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I can understand internal scars (lesions and adhesions) but what about external scarring?
It will still work on surface scarring just as it will on diabetic ulcers and the similar problems. By continually digesting the scar tissue, healthy tissue will eventually replace the old scar. It may not complete eradicate all of the scarring but the worse the scarring the better the visual benefits.
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I wanted to know if Serrapeptase clears external scar tissue.
Yes, but it is a slower process compared to internal scars. The scar will be flatter, but may not usually disappear completely without Rio Rosa Mosqueta Oil.
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Will there be any drug interaction with my seizure medicine tegretol & lamictal?
None whatsoever with any drug.
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I am on Warfarin, is it safe to take Serrapeptase?
Yes it is perfectly safe and if you follow my cardiovascular plan you may not need the Warfarin. Healthy people do not need drugs.
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Is Serrapeptase safe for use when taking blood pressure medication?
Yes, It may even help prevent the need for drugs
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Will this conflict with any drugs I am taking or cause my blood to become to thin?
There are many opinions about what to take with what and what is a so called 'blood thinner'. Firstly Aspirin is NOT a blood thinner such as Warfarin. Aspirin is an anti-inflammatory as are all proteolytic enzymes. They cause the blood to flow normally, not thinner than normal by stopping the inflammation in the blood stream that causes blood clotting. The prime cause of western diseases is now considered to be chronic inflammation caused by eating starchy carbohydrates, processed, micro-waved and generally overcooked foods. This is measured by the rise in C-Reactive proteins after eating such foods. When we have chronic inflammation as well as free radical damage, we get what is known as sticky blood, where the platelets stick together and can clot.
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Can it be taken with other medication and do I need to inform my Doctor?
Yes it can be taken with any medication and may mean that you will be able to stop taking them.
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Can it be used on animals such as cat and dogs?
Yes it has proven to be very effective on all animals. Many veterinarians are now prescribing it as well as arthritic pet owners sharing their own bottle with their arthritic dog to great effect. (read the testimonies)
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My son has Crohn's Disease, he is 10 years old can he take these tablets and how many?
He can take any amount, as they are quite safe. I would try 3 per day to begin. He also needs to follow the recovery plan to resolve it (please refer to the Serrapeptase book).
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If the tablets are enteric coated, does it not destroy that coating to chew the tablets - e.g. in the case of a child?
Well spotted, nobody else has asked this question. The answer is that some will be absorbed in the mouth, some will inactivated by the stomach, some will absorb in the throat, and some will get through into the small intestine. Enough will get through to do the job and especially in a child. It has worked twice on me to get rid of a sore throat in around 30 minutes
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What is the Clinical usage of Serrapeptase in children, with dosage precautions and other relevant clinical information?
It can be safely used with children. I recommend 1-3 tablets per day for children. If they cannot swallow the tablets, they can chew the tablet as it does not have any taste. (also capsules that can be broken open and mixed with honey). In fact a sore throat can be cleared in about 30 minutes by chewing 1-2 tablets. Our grandchildren use it when they get mucus problems from colds, with fast results.
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How long has Serrapeptase been in use?
Around 25-35 years.
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Where can I purchase Serrapeptase? Can it be purchased in Australia? If not can it be imported into Australia?
It cannot be purchased directly in Australia, but can be bought on-line and imported for private use
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My research indicates that Serrapeptase is destroyed by stomach acid and therefore needs to be enteric-coated. Do you have research that shows otherwise?
No, I recommend enteric-coated tablets and enteric-coated granules in capsules for the best delivery.
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I have recently begun a supplement program, which includes 140 mg of Serrapeptase daily. This seems close to your max dosage of 150 mg for, for example, acute trauma. Is it safe to take 140 mg daily indefinitely? If not, what would you recommend as a max daily dose?
Lets talk in terms of IU International Units instead of Mg. A tablet or capsule may be 5000IU, 10,000IU, 20,000IU or 40,000IU There is no real upper limit other than you may get stomachache. I recommend an upper limit of 9 of the 40,000IU daily. This is only because I have not observed any better result in excess of this.
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Does it thin the blood?
No it does NOT thin the blood. It makes it healthier by stopping the chronic inflammation that is the cause of our health problems. You need to read my book on Serrapeptase to get a full understanding.
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If the results tabulated are so beneficial to sufferers, why is this product so little known?
Serrapeptase is the best-kept secret because the drug industry does not like non-patented natural competitors to their high priced drugs. You may not know this but this enzyme is available on prescription in Germany and Austria which both have much better medical care systems compared to the UK.
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Who makes this product?
The enzyme, Serrapeptase, is grown in the Far East and a processor in the USA makes it into tablets and capsules
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What is Serrapeptase?
Serrapeptase is a proteolytic enzyme isolated from the micro-organism, Serratia E15. This enzyme is naturally present in the silkworm intestine and is processed commercially today through fermentation. This immunologically active enzyme is completely bound to the alpha 2 macroglobulin in biological fluids. Histological studies reveal powerful anti-inflammatory effects of this naturally occurring enzyme.
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Has it any side effects or can I take too many?
No side effects have been found in over 25 years of studies and usage. Many people take very high doses to speed-up the relief e.g. in cases of sports injuries which can be as high as 30 per day with no side effects whatsoever except a faster recovery. It is even safe for children of 2 years+ for a wide range of conditions: (asthma, lung problems, arthritis, etc).
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Why can it benefit so many different conditions?
Although Serrapeptase simply digests dead and inflamed tissue these two problems are the cause of the majority of symptoms in the body. The wide range of conditions that respond to Serrapeptase include: - Varicose Veins and other circulatory problems - Pain problems such as, Arthritis, Joints, and Muscles Pains and even MS. - Lung Diseases such as Emphysema, Asthma, Bronchitis and Bronchiectasis - Sinus and other ENT problems - Post Operative Healing, Lesions and Cysts (breast, ovarian etc) - Arterial Plaque, DVT (good for travellers) and Blood Clots - Migraines (vascular). - Enlarged Prostate and many more (please see Serrapeptase book for references to the studies )
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Are there any animal products within your product?
No. They are plant grown enzymes
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You say suitable for vegetarians, yet I read that this comes from a silkworm? Does it or does it not?
It is produced by a bacteria grown in beans that was originally noticed over 30 years ago being used by the silkworm in its cocoon to dissolve proteins. They are actually plant grown enzymes.
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How does Serrapeptase help sinusitis?
Serrapeptase has many studies showing that it helps the sinus in two ways. The first is to stop the inflammation that stimulates the mucus and the second is to clear out the mucus completely. It usually does this within hours or at most a day or so. As it is a simple enzyme it has no side effects whatsoever.
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Can it get rid of my varicose veins completely?
It can get rid of the discomfort and the swollen veins (ask my grateful wife). It cannot repair damaged valves.
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Can this also help varicose veins?
Yes it is very useful and stop the pain and in some cases reduces them as well.
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Are you sure Serrapeptase is safe for cystic fibrosis?
There was one report out of the millions of doses taken worldwide that claimed a Japanese persons lung infection was due to the Serrapeptase. This was illogical for a number of reasons: 1. The Serrapeptase has had studies to show that it reduces infections. 2. Studies show that it speeds up the effect of antibiotics. 3. This report was not studied nor was a scientific explanation give. 4. It could simply have been coincidence. 5. It is used as a primary treatment for lung diseases by many and a direct cause would have revealed itself in the last 30 years. After saying all that; By taking the Curcumin which is a powerful anti viral, anti-bacterial and anti-fungal not to mention anti-inflammatory and stimulator of glutathione (one of the critical antioxidants for the lungs) even if their had been the slightest chance of infection then this would stop that dead.
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